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Results for "

death receptor 5 (DR5)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) MDM-2/p53 (1) TNF Receptor (2)
By Research Areas:	Cancer (4)

4

Inhibitors & Agonists

3

Inhibitory Antibodies

6

Recombinant Proteins

Targets Recommended: DAPK PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Benufutamab GEN1029	TNF Receptor Apoptosis	Cancer
Benufutamab (GEN1029) is a **death receptor 5 (DR5)**-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .

Conatumumab AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody	TNF Receptor	Cancer
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (K_d: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .

Tigatuzumab CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody	Apoptosis	Cancer
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .

P53R3	MDM-2/p53	Cancer
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 ^R175H, p53 ^R248W and p53 ^R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 ^M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the **death receptor death receptor 5 (DR5)**. P53R3 is used for cancer research .

Species:	Human (2) Mouse (4)
Tag:	His (3) Tag Free (1) Avi (1) Fc (3)
Source:	HEK293 (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	TRAIL R2/TNFRSF10B Protein, Human Tumor necrosis factor receptor superfamily member 10B; death receptor 5; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	E. coli
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by E. coli , with tag free. The total length of TRAIL R2/TNFRSF10B Protein, Human is 132 a.a., with molecular weight of ~14.8 kDa.

	TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) Tumor Necrosis Factor receptor Superfamily Member 10B; death receptor 5; TNF-Related Apoptosis-Inducing Ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.0 kDa.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) Tumor necrosis factor receptor superfamily member 10B; death receptor 5; CD262; Tnfrsf10b; Dr5; Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is 125 a.a., with molecular weight of 50-55 kDa.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) Tumor necrosis factor receptor superfamily member 10B; death receptor 5; MK; CD262; Tnfrsf10b; Dr5; Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is 125 a.a., with molecular weight of 20-40 kDa.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK 293, hFc) Tnfrsf10b; Dr5; Killer; Tumor necrosis factor receptor superfamily member 10B; death receptor 5; MK; CD antigen CD262	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK 293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK 293, hFc) is 125 a.a., with molecular weight of ~50 kDa.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) Tumor necrosis factor receptor superfamily member 10B/death receptor 5/MK/CD262/Tnfrsf10b/Dr5/Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is 125 a.a., with molecular weight of 50-75 kDa.

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